Milhealth’s Directory of Military Health Information Resources » Use of Eszopiclone and Zolpidem for PTSD (Contextual Memory)

Use of Eszopiclone and Zolpidem for PTSD (Contextual Memory)

Research report

Abstract

At present, previous termeszopiclonenext term and zolpidem are the most commonly prescribed drugs for treating insomnia. Despite the established relationship between sleep disturbance and anxiety, it remains unknown whether targeted treatment for insomnia may affect acute anxiety. Therefore, the objective of this study was to examine the effects of three different doses (1, 3, and 10 mg/kg) of previous termeszopiclonenext term and zolpidem on the states of sleep and wakefulness, levels of anxiety-like behavior, and long-term contextual memory in footshock-induced anxious rats.

The results of this study demonstrated that the administration of previous termeszopiclonenext term and zolpidem both were equally effective in attenuating footshock stressor-induced suppression of slow-wave sleep (SWS).

The administration of previous termeszopiclonenext term at 1 mg/kg or zolpidem at 1 and 3 mg/kg doses showed a tendency for attenuating stressor-induced suppression of REM sleep. However, the REM sleep attenuating effects of these drugs disappeared when they were administered at higher doses.

The administration of previous termeszopiclonenext term at 3 and 10 mg/kg doses and zolpidem at all three doses reduced the power of electroencephalographic theta band frequencies during wakefulness.

In addition, the administration of previous termeszopiclonenext term at 1 and 3 mg/kg doses suppressed stressor-induced anxiety-like behavior.

The administration of zolpidem at 1, 3, or 10 mg/kg doses was not effective in attenuating stressor-induced anxiety-like behavior.

  • Contextual memory after administration of previous termeszopiclonenext term at 1 mg/kg dose had no effects, but was reduced significantly with increased dosage.
  • Contextual memory after administration of zolpidem, at all three doses, was severely disrupted.

The results of this study suggest that previous termeszopiclonenext term at a low dose could be used effectively to control anxiety and anxiety-induced insomnia.

AUTHOR/AFFILIATIONS

Max P. Huanga, Kushan Radadiaa, Brian W. Maconea, Sanford H. Auerbachab and Subimal DattaabcCorresponding Author Contact InformationE-mail The Corresponding Author

a Laboratory of Sleep and Cognitive Neurosciences, Department of Psychiatry, Boston University School of Medicine, 85 East Newton Street, M-902, Boston, MA 02118, USA

b Department of Neurology, Boston University School of Medicine, 85 East Newton Street, M-902, Boston, MA 02118, USA

c Department of Neuroscience, Boston University School of Medicine, 85 East Newton Street, M-902, Boston, MA 02118, USA

CITATION

Huang MP, Radadia K, Macone BW, et al. Effects of eszopiclone and zolpidem on sleep-wake behavior, anxiety-like behavior and contextual memory in rats. Behavioural Brain Research. 2010;210(1):54-66. Available at: http://www.sciencedirect.com/science/article/B6SYP-4YCFYWM-4/2/fcd409498437f22e121476e93d2771d2 [Accessed July 16, 2010].

KEYWORDS 

Eszopiclonenext term; Zolpidem; REM sleep; Slow-wave sleep; Wakefulness; Anxiety; Contextual memory; Rat

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Author: Chilleh Penguin

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