At present, eszopiclone and zolpidem are the most commonly prescribed drugs for treating insomnia. Despite the established relationship between sleep disturbance and anxiety, it remains unknown whether targeted treatment for insomnia may affect acute anxiety. Therefore, the objective of this study was to examine the effects of three different doses (1, 3, and 10 mg/kg) of eszopiclone and zolpidem on the states of sleep and wakefulness, levels of anxiety-like behavior, and long-term contextual memory in footshock-induced anxious rats.
The administration of eszopiclone at 1 mg/kg or zolpidem at 1 and 3 mg/kg doses showed a tendency for attenuating stressor-induced suppression of REM sleep. However, the REM sleep attenuating effects of these drugs disappeared when they were administered at higher doses.
The administration of zolpidem at 1, 3, or 10 mg/kg doses was not effective in attenuating stressor-induced anxiety-like behavior.
- Contextual memory after administration of eszopiclone at 1 mg/kg dose had no effects, but was reduced significantly with increased dosage.
- Contextual memory after administration of zolpidem, at all three doses, was severely disrupted.
a Laboratory of Sleep and Cognitive Neurosciences, Department of Psychiatry, Boston University School of Medicine, 85 East Newton Street, M-902, Boston, MA 02118, USA
b Department of Neurology, Boston University School of Medicine, 85 East Newton Street, M-902, Boston, MA 02118, USA
c Department of Neuroscience, Boston University School of Medicine, 85 East Newton Street, M-902, Boston, MA 02118, USA